bioconductor-spsimseq
SPsimSeq uses a specially designed exponential family for density estimation to constructs the distribution of gene expression levels from a given real RNA sequencing data (single-cell or bulk), and subsequently simulates a new dataset from the estimated marginal distributions using Gaussian-copulas to retain the dependence between genes. It allows simulation of multiple groups and batches with any required sample size and library size.
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1.8.0, 1.4.0, 1.2.0, 1.16.0, 1.12.0, 1.10.0, 1.0.0
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